Нейроофтальмологічні порушення при над'ядерному паралічі

Authors

  • Ludmila Venger Odesa National Medical University
  • I.V. Khubetova Odesa regional clinical hospital, Odesa (Ukraine)

Keywords:

progressive supranuclear palsy, neuroophthalmology, diagnostic assessment, phenotype

Abstract

http://doi.org/10.31288/oftalmolzh202253741

UDC 617.7-06:616.831.8-008.6

Background: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonism with various movement disorders and oculomotoric abnormalities.

Purpose: To identify major neuroophthalmic manifestations in different clinical phenotypes of PSP.

Material and Methods: The study was conducted at the Odesa regional clinical hospital in 2011 to 2021.

Twenty one patients with PSP (including one patient with PSP combined with Hallervorden–Spatz disease and levodopa-induced hyperkynesis) underwent an examination. This included a classical neurological examination and comprehensive neuroophthalmic examination with high-field magnetic resonance imaging (MRI) of the brain and spine and videonystagmography testing. Mean patient age was 53.2 ± 1.1 years, and most patients were women (13 [61.9%]). Statistical analysis included frequency analysis.

Results: PSP-P was the most common phenotype of PSP (52.4%), followed by PSP-PGF (9.5%), PSP-OM (9.5%), PSP-PI (9.5%), PSP-CBS (4.8%), PSP-SL (4.8%), PSP-F (4.8%) and PSP+GSD (4.8%). All patients showed changes in velocity and amplitude of vertical saccades. Diplopia was, however, observed in only 12 (57.1%) patients.

Conclusion: Neurological and neuroophthalmic examination is decisive in establishing the diagnosis of progressive supranuclear palsy and selecting a treatment strategy. In the current study, PSP-P was the most common (52.4%) phenotype,  the frequency of PSP-OM variant was 9.5%.

Author Biographies

Ludmila Venger, Odesa National Medical University

Д-р мед. наук, професор, завідувачка кафедри офтальмології

I.V. Khubetova, Odesa regional clinical hospital, Odesa (Ukraine)

К.мед.н., доцент, завідувачка відділення неврології

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Published

2022-11-15

How to Cite

1.
Venger L, Khubetova I. Нейроофтальмологічні порушення при над’ядерному паралічі. J.ophthalmol.(Ukraine) [Internet]. 2022 Nov. 15 [cited 2023 Feb. 5];(5):37-41. Available from: https://ojs.ozhurnal.com/index.php/files/article/view/202

Issue

Section

Clinical Ophthalmology