Using a liposomal ozone-based solution in comprehensive treatment of bacterial keratitis


  • Олена Алексєєва Dnipro State Medical University; Dnipro (Ukraine)
  • V.M. Sakovych Dnipro State Medical University; Dnipro (Ukraine)


bacterial keratitis, liposomal ozone-based solution, comprehensive treatment, clinical scores


UDC  617.713-002-022.7-085.457/.835

Background: Keratitis is an inflammatory eye disease frequently leading to complications, significantly decreased vision and visual disability. Common infectious agents include, in particular, aggressive Gram-negative microflora and opportunistic bacteria. The use of conventional antibacterial therapy does not guarantee a positive treatment effect. Infections caused by antibiotic-resistant germs frequently result in increased hospitalization rates with an increased length of inpatient stay at hospital and can cause severe corneal opacities. Formation of biofilms is a cause of increased antibiotic resistance.

Purpose: To improve the efficacy of treatment of bacterial keratitis by integrating an adjunctive liposomal ozone-based solution into comprehensive treatment.

Material and Methods: Forty-four patients (44 eyes) with bacterial keratitis, aged from 29 to 75 years, were involved in the study. Patients were divided into an ozone group of 21 patients and a control group of 23 patients. All patients were administered antibacterial therapy, mydriatics, desensibilizing agents, tissue preparations and vitamins. In addition, patients of the ozone group received an eye drop of ozone-based solution four times a day for 10 days.

Results: The method allowed for a significant (р < 0.001) reduction in conjunctival discharge, mixed conjunctival injection, corneal edema and inflammatory response, leeading to a 3.3 ± 0.1 day reduction in the length of inpatient stay at the hospital.

Conclusion: Utilizing a liposomal ozone-based solution as an adjunct to the comprehensive treatment of bacterial keratitis is a novel treatment method making it possible to accelerate corneal epithelization and reduction in inflammation, and to shorten the length of treatment.

Author Biographies

Олена Алексєєва, Dnipro State Medical University; Dnipro (Ukraine)

Асистент кафедри офтальмології

V.M. Sakovych, Dnipro State Medical University; Dnipro (Ukraine)

Доктор медичних наук, професор кафедри офтальмології


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How to Cite

Алексєєва О, Sakovych V. Using a liposomal ozone-based solution in comprehensive treatment of bacterial keratitis. J.ophthalmol.(Ukraine) [Internet]. 2022 Nov. 15 [cited 2023 Feb. 5];(5):19-22. Available from:



Clinical Ophthalmology